DNA repair protein rad10
|Ercc1 and XPF (xeroderma pigmentosum group F-complementing protein) are two structure-specific endonucleases of a class of seven containing an ERCC4 domain. Together they form an obligate complex that functions primarily in nucleotide excision repair (NER), a versatile pathway able to detect and remove a variety of DNA lesions induced by UV light and environmental carcinogens, and secondarily in DNA interstrand cross-link repair and telomere maintenance. This domain in fact binds simultaneously to both XPF and single-stranded DNA; this ternary complex explains the important role of Ercc1 in targeting its catalytic XPF partner to the NER pre-incision complex .|
|Literature||1. Xu H, Swoboda I, Bhalla PL, Sijbers AM, Zhao C, Ong EK, Hoeijmakers JH, Singh MB; Plant J. 1998;13:823-829.Plant homologue of human excision repair gene ERCC1 points to conservation of DNA repair mechanisms. PUBMED:9681020|
2. Park Y, Gerson SL; Annu Rev Med. 2005;56:495-508.DNA repair defects in stem cell function and aging. PUBMED:15660524
3. Tripsianes K, Folkers GE, Zheng C, Das D, Grinstead JS, Kaptein R, Boelens R; Nucleic Acids Res. 2007;35:5789-5798.Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization. PUBMED:17720715
The seed alignment for this family in the PANDIT database contains 7 aligned sequences:
| || ERCC1_ARATH/124-191 ERCC1_HUMAN/99-166 O96136_PLAF7/46-113 Q93456_CAEEL/49-118 Q9Y0X3_DROME/61-129 RAD10_YEAST/91-163 SWI10_SCHPO/41-108 |
The full alignment for this family in the Pfam database contains 142 aligned sequences
Species in the seed alignment
List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each organism.
| ||Saccharomyces cerevisiae (1); Caenorhabditis elegans (1); Homo sapiens (1); Schizosaccharomyces pombe (1); Drosophila melanogaster (1); Plasmodium falciparum 3D7 (1); Arabidopsis thaliana (1);|
The full alignment covers 91 species.
Pre-computed estimates from Markov codon substitution models (explanation)
Following are maximum-likelihood estimates and log-likelihood scores from codon models M0, M1, M2, M7 and M8, implemented in PAML v.4.1
Maximum-likelihood estimates and log-likelihood scores from codon models Nonsynonymous and Dual implemented in HYPHY
|Interactions||This family has 0 known interactions:|
|Structures||This family has 3 structures:|
|Notation: PDB_ID (PDB chain, PDB residues)|
|KEGG Pathways - for genes coding for sequences from full alignment|
Expression data (explanation)
|Bgee expression data - for genes coding for sequences from seed alignment Click here for overview of Bgee data|
The numbers in brackets correspond to the number of genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.
|HumanProteinpedia expression data - for human genes coding for sequences from full alignment Click here for overview of Human Proteinpedia data|
The numbers in brackets correspond to the number of human genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.
Human disease association
|Genetic Association Database - data for human genes coding for sequences from full alignment|
The numbers in brackets correspond to the number of genes that are associated with the selected family and are associated with the corresponding disease. Click on the disease name to see all the families possibly associated with that disease and click on the genes to see the corresponding genes.
|Associated diseases and disorders|
|Links to OMIM - for human genes coding for sequences from full alignment|