PANDIT+

KeywordFamilyClanGene   

Entry: DUF1670 (PF07900) * this family does not contain any human sequence in the seed alignment although some of the annotation data are human specific [read more]

Display a clan
Very fast search for clan entries. The
search can be done either by clan ID
(e.g. CL0192) or by clan name (e.g. GPCR_A).
Display a clan
Very fast search for clan entries. The
search can be done either by clan ID
(e.g. CL0192) or by clan name (e.g. GPCR_A).

Pfam summary

Description

Protein of unknown function (DUF1670)

The hypothetical eukaryotic proteins found in this family are of unknown function.
 
Literature
 
Clan

CL0123 (HTH)

The clan contains the following members: PF04218(CENP-B_N); PF01381(HTH_3); PF02954(HTH_8); PF04760(IF2_N); PF00249(Myb_DNA-binding); PF01399(PCI); PF03399(SAC3_GANP); PF04542(Sigma70_r2); PF04545(Sigma70_r4); PF00440(TetR_N); PF00486(Trans_reg_C); PF01316(Arg_repressor); PF04182(B-block_TFIIIC); PF00325(Crp); PF01978(TrmB); PF02001(DUF134); PF02650(DUF199); PF01638(DUF24); PF03444(DUF293); PF04079(DUF387); PF02319(E2F_TDP); PF03789(ELK); PF00178(Ets); PF04703(FaeA); PF02742(Fe_dep_repr_C); PF01325(Fe_dep_repress); PF01475(FUR); PF00196(GerE); PF00392(GntR); PF00046(Homeobox); PF00447(HSF_DNA-bind); PF00126(HTH_1); PF04967(HTH_10); PF01022(HTH_5); PF01418(HTH_6); PF02796(HTH_7); PF00165(HTH_AraC); PF03811(Ins_element1); PF00356(LacI); PF01726(LexA_DNA_bind); PF01047(MarR); PF00376(MerR); PF05043(Mga); PF03962(Mnd1); PF02316(Mu_DNA_bind); PF03551(PadR); PF00292(PAX); PF03965(Pencillinase_R); PF00157(Pou); PF03288(Pox_D5); PF01051(Rep_3); PF04796(RepA_C); PF02257(RFX_DNA_binding); PF05158(RNA_pol_Rpc34); PF03428(RP-C); PF02334(RTP); PF04963(Sigma54_CBD); PF04552(Sigma54_DBD); PF04539(Sigma70_r3); PF02002(TFIIE_alpha); PF01710(Transposase_14); PF01498(Transposase_5); PF01527(Transposase_8); PF03221(Transposase_Tc5); PF01371(Trp_repressor); PF02082(Rrf2); PF04297(UPF0122); PF02295(z-alpha); PF05225(HTH_psq); PF05269(Phage_CII); PF05331(DUF742); PF05339(DUF739); PF05584(Sulfolobus_pRN); PF05732(RepL); PF05920(Coprinus_mating); PF05930(Phage_AlpA); PF06056(Terminase_5); PF06163(DUF977); PF06504(RepC); PF06530(Phage_antitermQ); PF06576(DUF1133); PF06627(DUF1153); PF06970(RepA_N); PF06971(Put_DNA-bind_N); PF07022(Phage_CI_repr); PF07037(DUF1323); PF07042(TrfA); PF07106(TBPIP); PF07278(DUF1441); PF07374(DUF1492); PF07381(DUF1495); PF07453(NUMOD1); PF07544(CSE2); PF07638(Sigma70_ECF); PF07750(GcrA); PF07825(Exc); PF07848(PaaX); PF07900(DUF1670); PF08100(Dimerisation);
 
InterPro entry
 

Alignment

New Hampshire tree

The seed alignment for this family in the PANDIT database contains 6 aligned sequences:

  Q8PYY6_METMA/26-245   Q8PYY7_METMA/6-215   Q8TH36_METAC/30-238   Q8TH52_METAC/26-244   Q8TKL1_METAC/20-233   Q8TKL2_METAC/27-244  

The full alignment for this family in the Pfam database contains 34 aligned sequences

Species in the seed alignment

List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each organism.

  Methanosarcina acetivorans (4);   Methanosarcina mazei (2);  

The full alignment covers 7 species.

Pre-computed estimates from Markov codon substitution models (explanation)

Following are maximum-likelihood estimates and log-likelihood scores from codon models M0, M1, M2, M7 and M8, implemented in PAML v.4.1

Model name  

Model M0

Model M1

Model M2

Model M7

Model M8

Log-likelihood score  

-4295.37-4261.442247-4261.442281-4252.494949-4248.458774

Tree Length  

260.12260.11824260.11824260.11824260.11824

κ  

1.191.2946981.2946751.2888621.230913

ω-ratio  

ω=0.00536p0=0.768833 ~ ω0=0.007155
p1=0.231167 ~ ω1=1
p0=0.768833 ~ ω0=0.007156
p1=0.231165 ~ ω1=1
p2=2e-06 ~ ω2=19.080287
ω~Β(0.972247,99)p0=0.912561 ~ ω~Β(1.706344,99)
p1=0.087439 ~ ω=5.422646

P-value for testing  
positive selection  

M1 vs M2: P-value=1
family classification: conserved
M7 vs M8: P-value=0.017665
family classification: positively selected

Positively selected sites - the underlined numbers denote the position in the AA sequence, while the number in brackets denote the estimated probability for having positive selection at that position. Only positions where the estimated probability for positive selection is ≥0.95 are shown.

   Model M8:

Maximum-likelihood estimates and log-likelihood scores from codon models Nonsynonymous and Dual implemented in HYPHY

Model name  

Model Nonsynonymous

Model Dual

Log-likelihood score  

-4470.33741-4470.11778

Mean ω-ratio  

ω = 0.31108ω = 0.10168

Coeff. of variation  
of ω-ratio  

CVω = 1.7578CVω = 1.6367
 

Annotations

InteractionsThis family has 0 known interactions:

StructuresThis family has 0 structures:
Notation: PDB_ID (PDB chain, PDB residues)

Gene Ontologies

KEGG Pathways - for genes coding for sequences from full alignment
Metabolism
Carbohydrate Metabolism
Citrate cycle (TCA cycle) [KEGG]
Pentose phosphate pathway [KEGG]
Starch and sucrose metabolism [KEGG]
Energy Metabolism
Oxidative phosphorylation [KEGG]
Lipid Metabolism
Sphingolipid metabolism [KEGG]
Nucleotide Metabolism
Purine metabolism [KEGG]
Pyrimidine metabolism [KEGG]
Amino Acid Metabolism
Methionine metabolism [KEGG]
Lysine degradation [KEGG]
Glycan Biosynthesis and Metabolism
Other glycan degradation [KEGG]
Metabolism of Cofactors and Vitamins
One carbon pool by folate [KEGG]
Porphyrin and chlorophyll metabolism [KEGG]
Genetic Information Processing
Folding, Sorting and Degradation
SNARE interactions in vesicular transport [KEGG]
Replication and Repair
DNA replication [KEGG]
Base excision repair [KEGG]
Nucleotide excision repair [KEGG]
Homologous recombination [KEGG]
Environmental Information Processing
Signal Transduction
Two-component system [KEGG]
Cellular Processes
Cell Growth and Death
Cell cycle - yeast [KEGG]
 

Expression data (explanation)

 
Bgee expression data - for genes coding for sequences from seed alignment     Click here for overview of Bgee data

none


HumanProteinpedia expression data - for human genes coding for sequences from full alignment     Click here for overview of Human Proteinpedia data
 
Healthy tissues
Disease tissues

Human disease association

 
Genetic Association Database - data for human genes coding for sequences from full alignment
 
Associated diseases and disorders

Links to OMIM - for human genes coding for sequences from full alignment