Pfam summary |
| Description | Prolyl oligopeptidase, N-terminal beta-propeller domain |
| This unusual 7-stranded beta-propeller domain protects the catalytic triad of prolyl oligopeptidase (see Pfam:PF00326), excluding larger peptides and proteins from proteolysis in the cytosol. |
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| Literature | 1. Fulop V, Bocskei Z, Polgar L; Cell 1998;94:161-170.Prolyl oligopeptidase: an unusual beta-propeller domain regulates proteolysis. PUBMED:9695945
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| Clan | |
| The clan contains the following members: PF01011(PQQ); PF00780(CNH); PF03178(CPSF_A); PF00930(DPPIV_N); PF01839(FG-GAP); PF04762(IKI3); PF03022(MRJP); PF01436(NHL); PF02897(Peptidase_S9_N); PF00400(WD40); PF01731(Arylesterase); PF04053(Coatomer_WDAD); PF02239(Cytochrom_D1); PF05096(Glu_cyclase_2); PF00058(Ldl_recept_b); PF00415(RCC1); PF03088(Str_synth); PF05694(SBP56); PF05787(DUF839); PF06433(Me-amine-dh_H); PF06739(SBBP); PF07433(DUF1513); PF07494(Reg_prop); PF07676(PD40); |
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| InterPro entry |
IPR004106 |
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Alignment |
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The seed alignment for this family in the PANDIT database contains 31 aligned sequences: |
| | O05748_MYCLE/10-432 O07178_MYCTU/3-407 O07834_PSESP/29-445 O70196_RAT/6-423 O76728_TRYBB/19-433 PPCE_AERHY/8-410 PPCE_BOVIN/6-423 PPCE_FLAME/28-429 PPCE_HUMAN/6-423 PPCE_MOUSE/6-423 PPCE_PIG/6-423 PPCF_FLAME/28-429 PTRB_ECOLI/2-404 PTRB_MORLA/3-405 Q94795_TRYCR/17-432 Q9RBG8_AERPU/9-411 Q9RRI7_DEIRA/5-415 Q9SGR9_ARATH/77-501 Q9SX53_ARATH/6-429 Q9UM02_HUMAN/6-423 Q9V9P5_DROME/27-442 Q9VKW5_DROME/50-467 Q9X5N2_MYXXA/3-406 Q9X6R4_AERPU/9-411 Q9XYH4_LEIMA/26-447 Q9XZR9_DICDI/5-478 Q9ZDP6_RICPR/3-407 Q9ZNM8_9SPHN/40-450 Y4NA_RHISN/20-455 Y4QF_RHISN/39-446 Y4SO_RHISN/7-415
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The full alignment for this family in the Pfam database contains 1170 aligned sequences
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Species in the seed alignment |
List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each
organism. |
| | Rhizobium sp. NGR234 (3); Drosophila melanogaster (2); Homo sapiens (2); Arabidopsis thaliana (2); Aeromonas punctata (2); Elizabethkingia miricola (1); Mus musculus (1); Elizabethkingia meningoseptica (1); Rickettsia prowazekii (1); Aeromonas hydrophila (1); Leishmania major (1); Rattus norvegicus (1); Mycobacterium tuberculosis (1); Deinococcus radiodurans (1); Trypanosoma cruzi (1); Escherichia coli K12 (1); Sus scrofa (1); Novosphingobium capsulatum (1); Bos taurus (1); Dictyostelium discoideum (1); Trypanosoma brucei brucei (1); Myxococcus xanthus (1); Pseudomonas sp. (1); Mycobacterium leprae (1); Moraxella lacunata (1); |
The full alignment covers 442 species. |
Pre-computed estimates from Markov codon substitution models (explanation) |
Following are maximum-likelihood estimates and log-likelihood scores from codon models
M0, M1, M2, M7 and M8, implemented in PAML v.4.1 |
Model name |
Model M0 | Model M1 |
Model M2 | Model M7 | Model M8 | Log-likelihood score | -28796.79 | -28793.552588 | -28793.552588 | -28549.391737 | -28549.391897 | Tree Length | 179.53 | 179.53496 | 179.53496 | 179.53496 | 179.53496 | κ | 1.55 | 1.557338 | 1.557335 | 1.557643 | 1.55764 | ω-ratio | ω=0.0424 | p0=0.991553 ~ ω0=0.043133
p1=0.00844699999999998 ~ ω1=1 | p0=0.991554 ~ ω0=0.043133
p1=0.008446 ~ ω1=1
p2=0 ~ ω2=35.6694 | ω~Β(2.850261,56.979039) | p0=0.999999 ~ ω~Β(2.850245,56.974979)
p1=1e-06 ~ ω=20.03607 | P-value for testing
positive selection
| | M1 vs M2: P-value=1
domain classification: conserved | M7 vs M8: P-value=1
domain classification: conserved |
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Maximum-likelihood estimates and log-likelihood scores from codon models
Nonsynonymous and Dual implemented in HYPHY |
Model name |
Model Nonsynonymous |
Model Dual | Log-likelihood score |
-34680.91252 | -34608.6039 |
Mean ω-ratio | ω =
0.0691 | ω = 0.06832 |
Coeff. of variation
of ω-ratio |
CVω = 2.40336 | CVω = 1.07276 |
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Annotations |
| Interactions | This domain has 2 known interactions: |
| PF00326; PF02897; |
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| Structures | This domain has 20 structures: |
| Notation: PDB_ID (PDB chain, PDB residues) |
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| Gene Ontologies | |
| | Biological Process | | | Molecular Function | |
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| KEGG Pathways
- for genes coding for sequences from full alignment |
| | Metabolism | | Energy Metabolism | | | Amino Acid Metabolism | | | Metabolism of Cofactors and Vitamins | |
| | Genetic Information Processing | | Folding, Sorting and Degradation | |
| | Cellular Processes | |
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| Bgee expression data - for genes coding for sequences from seed alignment
Click here for overview of Bgee data |
The numbers in brackets correspond to the number of genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes. |
| Homo sapiens |
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| Drosophila melanogaster |
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| Mus musculus |
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| HumanProteinpedia expression data
- for human genes coding for sequences from full alignment
Click here for overview of Human Proteinpedia data |
The numbers in brackets correspond to the number of human genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes. |
| Healthy tissues |
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| Disease tissues |
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Human disease association |
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| Genetic Association Database
- data for human genes coding for sequences from full alignment |
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| Associated diseases and disorders |
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| Links to OMIM
- for human genes coding for sequences from full alignment |
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| 609557
(1) 600400
(1) |
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