Cell division protein
|Members of this family include CDC3, CDC10, CDC11 and CDC12/Septin. Members of this family bind GTP. As regards the septins, these are polypeptides of 30-65kDa with three characteristic GTPase motifs (G-1, G-3 and G-4) that are similar to those of the Ras family. The G-4 motif is strictly conserved with a unique septin consensus of AKAD. Most septins are thought to have at least one coiled-coil region, which in some cases is necessary for intermolecular interactions that allow septins to polymerise to form rod-shaped complexes. In turn, these are arranged into tandem arrays to form filaments. They are multifunctional proteins, with roles in cytokinesis, sporulation, germ cell development, exocytosis and apoptosis .|
|Literature||1. Casamayor A, Snyder M; Mol Cell Biol 2003;23:2762-2777.Molecular dissection of a yeast septin: distinct domains are required for septin interaction, localization, and function. PUBMED:12665577|
2. Kinoshita M; Genome Biol 2003;4:236.The septins. PUBMED:14611653
|The clan contains the following members: PF00004(AAA); PF03029(ATP_bind_1); PF02492(cobW); PF00270(DEAD); PF03796(DnaB_C); PF05127(DUF699); PF00009(GTP_EFTU); PF00271(Helicase_C); PF00225(Kinesin); PF03354(Terminase_1); PF02463(SMC_N); PF00448(SRP54); PF00685(Sulfotransfer_1); PF03567(Sulfotransfer_2); PF01591(6PF2K); PF00005(ABC_tran); PF02456(Adeno_IVa2); PF00709(Adenylsucc_synt); PF00406(ADK); PF03969(AFG1_ATPase); PF04548(AIG1); PF01583(APS_kinase); PF01637(Arch_ATPase); PF00025(Arf); PF03308(ArgK); PF02374(ArsA_ATPase); PF00006(ATP-synt_ab); PF00308(Bac_DnaA); PF01656(CbiA); PF01121(CoaE); PF02572(CobA_CobO_BtuR); PF02283(CobU); PF02224(Cytidylate_kin); PF02499(DNA_pack_C); PF02500(DNA_pack_N); PF01712(dNK); PF03193(DUF258); PF03237(DUF264); PF03266(DUF265); PF03976(PPK2); PF01935(DUF87); PF00350(Dynamin_N); PF00519(PPV_E1_C); PF04257(Exonuc_V_gamma); PF02421(FeoB_N); PF00142(Fer4_NifH); PF01268(FTHFS); PF01580(FtsK_SpoIIIE); PF00503(G-alpha); PF04466(Terminase_3); PF02263(GBP); PF00437(GSPII_E); PF00735(GTP_CDC); PF04670(Gtr1_RagA); PF00625(Guanylate_kin); PF02689(Herpes_Helicase); PF02399(Herpes_ori_bp); PF05049(IIGP); PF01715(IPPT); PF01745(IPT); PF01695(IstB); PF02606(LpxK); PF00493(MCM); PF01078(Mg_chelatase); PF01926(MMR_HSR1); PF03205(MobB); PF00488(MutS_V); PF00063(Myosin_head); PF00931(NB-ARC); PF01057(Parvo_NS1); PF02562(PhoH); PF04665(Pox_A32); PF00485(PRK); PF03215(Rad17); PF00071(Ras); PF00154(RecA); PF04851(ResIII); PF00910(RNA_helicase); PF00158(Sigma54_activat); PF01202(SKI); PF00176(SNF2_N); PF02223(Thymidylate_kin); PF00265(TK); PF00693(Herpes_TK); PF02534(TraG); PF03668(ATP_bind_2); PF02367(UPF0079); PF00580(UvrD-helicase); PF01443(Viral_helicase1); PF05496(RuvB_N); PF05621(TniB); PF05625(PAXNEB); PF05673(DUF815); PF05707(Zot); PF05729(NACHT); PF05783(DLIC); PF05872(DUF853); PF05876(Terminase_GpA); PF05879(RHD3); PF05894(Podovirus_Gp16); PF05970(DUF889); PF06068(TIP49); PF06144(DNA_pol3_delta); PF06309(Torsin); PF06414(Zeta_toxin); PF06418(CTP_synth_N); PF06431(Polyoma_lg_T_C); PF06733(DEAD_2); PF06745(KaiC); PF06858(NOG1); PF06862(DUF1253); PF06990(Gal-3-0_sulfotr); PF07015(VirC1); PF07088(GvpD); PF07517(SecA_DEAD); PF07652(Flavi_DEAD); PF07693(KAP_NTPase); PF07724(AAA_2); PF07726(AAA_3); PF07728(AAA_5); PF07755(DUF1611); PF07931(CPT);|
The seed alignment for this family in the PANDIT database contains 16 aligned sequences:
| || CDC10_CANAL/34-313 CDC10_YEAST/29-308 CDC11_YEAST/19-305 CDC12_YEAST/31-321 CDC3_CANAL/32-314 CDC3_YEAST/116-418 PNUT_DROME/139-418 SEPT1_DROME/32-311 SEPT1_MOUSE/22-301 SEPT2_MOUSE/34-313 SEPT4_MOUSE/141-421 SPN3_SCHPO/49-332 SPN4_SCHPO/25-303 SPN5_SCHPO/115-377 SPN6_SCHPO/27-304 SPR3_YEAST/106-372 |
The full alignment for this family in the Pfam database contains 961 aligned sequences
Species in the seed alignment
List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each organism.
| ||Saccharomyces cerevisiae (5); Schizosaccharomyces pombe (4); Mus musculus (3); Candida albicans (2); Drosophila melanogaster (2);|
The full alignment covers 104 species.
Pre-computed estimates from Markov codon substitution models (explanation)
Following are maximum-likelihood estimates and log-likelihood scores from codon models M0, M1, M2, M7 and M8, implemented in PAML v.4.1
Maximum-likelihood estimates and log-likelihood scores from codon models Nonsynonymous and Dual implemented in HYPHY
|Interactions||This family has 1 known interaction:|
|Structures||This family has 7 structures:|
|Notation: PDB_ID (PDB chain, PDB residues)|
|KEGG Pathways - for genes coding for sequences from full alignment|
|DisProt- disorder annotation inferred from homologous DisProt sequences|
Expression data (explanation)
|Bgee expression data - for genes coding for sequences from seed alignment Click here for overview of Bgee data|
The numbers in brackets correspond to the number of genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.
|HumanProteinpedia expression data - for human genes coding for sequences from full alignment Click here for overview of Human Proteinpedia data|
The numbers in brackets correspond to the number of human genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.
Human disease association
|Genetic Association Database - data for human genes coding for sequences from full alignment|
The numbers in brackets correspond to the number of genes that are associated with the selected family and are associated with the corresponding disease. Click on the disease name to see all the families possibly associated with that disease and click on the genes to see the corresponding genes.
|Associated diseases and disorders|
|Links to OMIM - for human genes coding for sequences from full alignment|
|611737 (1) 604061 (1) 603151 (1) 612404 (1) 603696 (1) 612140 (1) 602207 (1) 604199 (1) 605950 (1) 608087 (1) 601506 (1) 300683 (1) 611562 (1) 300333 (1) 608314 (1) 602724 (1) 608418 (1)|