PANDIT+

KeywordFamilyClanGene   

Entry: ZZ (PF00569)

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Very fast search for clan entries. The
search can be done either by clan ID
(e.g. CL0192) or by clan name (e.g. GPCR_A).

Pfam summary

Description

Zinc finger, ZZ type

Zinc finger present in dystrophin, CBP/p300. ZZ in dystrophin binds calmodulin. Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2].
 
Literature1. Ponting CP, Blake DJ, Davies KE, Kendrick-Jones J, Winder SJ; Trends Biochem Sci 1996;21:11-13.ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. PUBMED:8848831
2. Roberts RG; Genome Biol 2001;2:REVIEWS3006.Dystrophins and dystrobrevins. PUBMED:11305946
 
Clan

CL0006 (C1)

The clan contains the following members: PF03107(C1_2); PF00130(C1_1); PF00569(ZZ); PF07649(C1_3); PF07975(C1_4);
 
InterPro entry IPR000433
 

Alignment

New Hampshire tree

The seed alignment for this family in the PANDIT database contains 10 aligned sequences:

  ADA2_YEAST/1-46   CBP1_CAEEL/1493-1532   CBP_MOUSE/1702-1743   DMD_CHICK/3304-3349   DMD_HUMAN/3307-3352   DMD_MOUSE/3300-3345   REF2P_DROME/121-165   RSC8_YEAST/254-298   UTRO_HUMAN/3064-3109   YOY6_CAEEL/8-52  

The full alignment for this family in the Pfam database contains 1017 aligned sequences

Species in the seed alignment

List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each organism.

  Homo sapiens (2);   Mus musculus (2);   Saccharomyces cerevisiae (2);   Caenorhabditis elegans (2);   Drosophila melanogaster (1);   Gallus gallus (1);  

The full alignment covers 124 species.

Pre-computed estimates from Markov codon substitution models (explanation)

Following are maximum-likelihood estimates and log-likelihood scores from codon models M0, M1, M2, M7 and M8, implemented in PAML v.4.1

Model name  

Model M0

Model M1

Model M2

Model M7

Model M8

Log-likelihood score  

-978.22-977.295742-977.295742-954.291274-954.291285

Tree Length  

209.97209.97248209.97248209.97248209.97248

κ  

1.261.2911541.2911361.7818891.781887

ω-ratio  

ω=0.00982p0=0.978343 ~ ω0=0.010411
p1=0.021657 ~ ω1=1
p0=0.978339 ~ ω0=0.010411
p1=0.021661 ~ ω1=1
p2=0 ~ ω2=24.874894
ω~Β(0.879374,43.270847)p0=0.999999 ~ ω~Β(0.879376,43.271004)
p1=1e-06 ~ ω=1

P-value for testing  
positive selection  

M1 vs M2: P-value=1
domain classification: conserved
M7 vs M8: P-value=1
domain classification: conserved

Maximum-likelihood estimates and log-likelihood scores from codon models Nonsynonymous and Dual implemented in HYPHY

Model name  

Model Nonsynonymous

Model Dual

Log-likelihood score  

-1108.08284-1078.07135

Mean ω-ratio  

ω = 0.04704ω = 0.01668

Coeff. of variation  
of ω-ratio  

CVω = 4.36367CVω = 0.52778
 

Annotations

InteractionsThis domain has 0 known interactions:

StructuresThis domain has 4 structures:
Notation: PDB_ID (PDB chain, PDB residues)

Gene Ontologies
Molecular Function
 zinc ion binding[GO:0008270]

KEGG Pathways - for genes coding for sequences from full alignment
Metabolism
Carbohydrate Metabolism
Pyruvate metabolism [KEGG]
Propanoate metabolism [KEGG]
Lipid Metabolism
Fatty acid biosynthesis [KEGG]
Nucleotide Metabolism
Purine metabolism [KEGG]
Pyrimidine metabolism [KEGG]
Xenobiotics Biodegradation and Metabolism
Drug metabolism - other enzymes [KEGG]
Genetic Information Processing
Transcription
RNA polymerase [KEGG]
Translation
Ribosome [KEGG]
Folding, Sorting and Degradation
Type II secretion system [KEGG]
Ubiquitin mediated proteolysis [KEGG]
Replication and Repair
Base excision repair [KEGG]
Homologous recombination [KEGG]
Environmental Information Processing
Signal Transduction
Wnt signaling pathway [KEGG]
Notch signaling pathway [KEGG]
TGF-beta signaling pathway [KEGG]
Jak-STAT signaling pathway [KEGG]
Signaling Molecules and Interaction
Cytokine-cytokine receptor interaction [KEGG]
Cellular Processes
Cell Growth and Death
Cell cycle [KEGG]
p53 signaling pathway [KEGG]
Cell Communication
Adherens junction [KEGG]
Endocrine System
Melanogenesis [KEGG]
Nervous System
Long-term potentiation [KEGG]
Development
Axon guidance [KEGG]
Human Diseases
Cancers
Pathways in cancer [KEGG]
Renal cell carcinoma [KEGG]
Prostate cancer [KEGG]
Acute myeloid leukemia [KEGG]
Neurodegenerative Diseases
Huntington's disease [KEGG]
 

Expression data (explanation)

 
Bgee expression data - for genes coding for sequences from seed alignment     Click here for overview of Bgee data

The numbers in brackets correspond to the number of genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.

Homo sapiens
Mus musculus

HumanProteinpedia expression data - for human genes coding for sequences from full alignment     Click here for overview of Human Proteinpedia data

The numbers in brackets correspond to the number of human genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes.

Healthy tissues
Disease tissues

Human disease association

 
Genetic Association Database - data for human genes coding for sequences from full alignment

The numbers in brackets correspond to the number of genes that are associated with the selected family and are associated with the corresponding disease. Click on the disease name to see all the families possibly associated with that disease and click on the genes to see the corresponding genes.

Associated diseases and disorders

Links to OMIM - for human genes coding for sequences from full alignment
 
611141 (1) 608790 (1) 128240 (1) 166945 (1) 602415 (1) 300377 (1) 604753 (1) 601530 (1) 608677 (1) 602700 (1) 300052 (1) 600140 (1) 605837 (1) 602276 (1) 605732 (1) 601239 (1)