Pfam summary |
| Description | Zinc finger, ZZ type |
| Zinc finger present in dystrophin, CBP/p300. ZZ in dystrophin binds calmodulin. Putative zinc finger; binding not yet shown. Four to six cysteine residues in its sequence are responsible for coordinating zinc ions, to reinforce the structure [2]. |
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| Literature | 1. Ponting CP, Blake DJ, Davies KE, Kendrick-Jones J, Winder SJ; Trends Biochem Sci 1996;21:11-13.ZZ and TAZ: new putative zinc fingers in dystrophin and other proteins. PUBMED:8848831
2. Roberts RG; Genome Biol 2001;2:REVIEWS3006.Dystrophins and dystrobrevins. PUBMED:11305946
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| Clan | |
| The clan contains the following members: PF03107(C1_2); PF00130(C1_1); PF00569(ZZ); PF07649(C1_3); PF07975(C1_4); |
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| InterPro entry |
IPR000433 |
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Alignment |
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The seed alignment for this family in the PANDIT database contains 10 aligned sequences: |
| | ADA2_YEAST/1-46 CBP1_CAEEL/1493-1532 CBP_MOUSE/1702-1743 DMD_CHICK/3304-3349 DMD_HUMAN/3307-3352 DMD_MOUSE/3300-3345 REF2P_DROME/121-165 RSC8_YEAST/254-298 UTRO_HUMAN/3064-3109 YOY6_CAEEL/8-52
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The full alignment for this family in the Pfam database contains 1017 aligned sequences
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Species in the seed alignment |
List of species covered in the seed alignment. The number in brackets denotes the number of sequences taken from each
organism. |
| | Caenorhabditis elegans (2); Homo sapiens (2); Mus musculus (2); Saccharomyces cerevisiae (2); Drosophila melanogaster (1); Gallus gallus (1); |
The full alignment covers 124 species. |
Pre-computed estimates from Markov codon substitution models (explanation) |
Following are maximum-likelihood estimates and log-likelihood scores from codon models
M0, M1, M2, M7 and M8, implemented in PAML v.4.1 |
Model name |
Model M0 | Model M1 |
Model M2 | Model M7 | Model M8 | Log-likelihood score | -978.22 | -977.295742 | -977.295742 | -954.291274 | -954.291285 | Tree Length | 209.97 | 209.97248 | 209.97248 | 209.97248 | 209.97248 | κ | 1.26 | 1.291154 | 1.291136 | 1.781889 | 1.781887 | ω-ratio | ω=0.00982 | p0=0.978343 ~ ω0=0.010411
p1=0.021657 ~ ω1=1 | p0=0.978339 ~ ω0=0.010411
p1=0.021661 ~ ω1=1
p2=0 ~ ω2=24.874894 | ω~Β(0.879374,43.270847) | p0=0.999999 ~ ω~Β(0.879376,43.271004)
p1=1e-06 ~ ω=1 | P-value for testing
positive selection
| | M1 vs M2: P-value=1
domain classification: conserved | M7 vs M8: P-value=1
domain classification: conserved |
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Maximum-likelihood estimates and log-likelihood scores from codon models
Nonsynonymous and Dual implemented in HYPHY |
Model name |
Model Nonsynonymous |
Model Dual | Log-likelihood score |
-1108.08284 | -1078.07135 |
Mean ω-ratio | ω =
0.04704 | ω = 0.01668 |
Coeff. of variation
of ω-ratio |
CVω = 4.36367 | CVω = 0.52778 |
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Annotations |
| Interactions | This domain has 0 known interactions: |
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| Structures | This domain has 4 structures: |
| Notation: PDB_ID (PDB chain, PDB residues) |
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| Gene Ontologies | |
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| KEGG Pathways
- for genes coding for sequences from full alignment |
| | Metabolism | | Carbohydrate Metabolism | | | Lipid Metabolism | | | Nucleotide Metabolism | | | Xenobiotics Biodegradation and Metabolism | |
| | Genetic Information Processing | | Transcription | | | Translation | | | Folding, Sorting and Degradation | | | Replication and Repair | |
| | Environmental Information Processing | | Signal Transduction | | | Signaling Molecules and Interaction | |
| | Cellular Processes | | Cell Growth and Death | | | Cell Communication | | | Endocrine System | | | Nervous System | | | Development | |
| | Human Diseases | | Cancers | | | Neurodegenerative Diseases | |
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| Bgee expression data - for genes coding for sequences from seed alignment
Click here for overview of Bgee data |
The numbers in brackets correspond to the number of genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes. |
| Homo sapiens |
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| Mus musculus |
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| HumanProteinpedia expression data
- for human genes coding for sequences from full alignment
Click here for overview of Human Proteinpedia data |
The numbers in brackets correspond to the number of human genes that are associated with the selected family and are expressed in the corresponding tissue. Click on the tissue to see all the families that possibly have function in that tissue and click on the genes to see the corresponding genes. |
| Healthy tissues |
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| Disease tissues |
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Human disease association |
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| Genetic Association Database
- data for human genes coding for sequences from full alignment |
The numbers in brackets correspond to the number of genes that are associated with the selected family and are associated with the corresponding disease. Click on the disease name to see all the families possibly associated with that disease and click on the genes to see the corresponding genes. |
| Associated diseases and disorders |
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| Links to OMIM
- for human genes coding for sequences from full alignment |
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| 608677
(1) 602700
(1) 300052
(1) 600140
(1) 605837
(1) 602276
(1) 605732
(1) 601239
(1) 611141
(1) 608790
(1) 128240
(1) 166945
(1) 602415
(1) 300377
(1) 604753
(1) 601530
(1) |
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